Synthesis of heparin partial structures and their binding activities to platelets

…, Y Suda, M Sobel, J Ormsby, S Kusumoto

Index: Koshida, Shuhei; Suda, Yasuo; Sobel, Michael; Ormsby, Julie; Kusumoto, Shoichi Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 21 p. 3127 - 3132

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Citation Number: 26

Abstract

A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [3H]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3, 6-di-O- ...