Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein …

BC Raimundo, JD Oslob, AC Braisted…

Index: Iyobe; Uchida; Kamata; Hotel; Kusama; Harada Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829

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Citation Number: 83

Abstract

... use these fragments to develop a new compound series that was chemically progressable and ... acetylene 4, a dipeptide guanidine fragment was introduced by standard peptide chemistry with Boc ... To replace the biaryl moiety, the chemical sequence from Scheme 1 was inverted ...