1, 4-Addition of (Diphenylmethylene) amine to Acceptor Substituted Olefins. A Versatile Synthesis of Protected β-Amino Acids, Nitriles, and Ketones
L Wessjohann, G Mcgaffin, A de Meijere
Index: Wessjohann, Ludger; McGaffin, Gregory; Meijere, Armin de Synthesis, 1989 , # 5 p. 359 - 363
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Citation Number: 28
Abstract
(Diphenylmethylene) amine [benzophenone iinine. DPMA-ll] cleanly reacts with a variety of ot.[l-unsaturated esters, nitriles. ketones, and aldehydes la-q to give Michael type adducts 2a— q, generally, in respectable to excellent yields. Sterically congested and donor~ substituted Michael acceptors do not react. The [i-amino-substituted products can be further transformed in their protected form, or sclec~ lively deproteeted under mild conditions, eg by catalytic ...
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