Chemistry Letters

One-pot synthesis of substituted quinolines by iridium-catalyzed three-component coupling reaction

T Igarashi, T Inada, T Sekioka, T Nakajima, I Shimizu

Index: Igarashi, Takeyuki; Inada, Takashi; Sekioka, Tadao; Nakajima, Takayuki; Shimizu, Isao Chemistry Letters, 2005 , vol. 34, # 1 p. 106 - 107

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Citation Number: 24

Abstract

A convenient and efficient synthesis of substituted quinolines in a simple one-pot reaction of an arylamine 1, an aromatic aldehyde or aliphatic aldehyde 2 and an aliphatic aldehyde 3 in the presence of transition metal complexes or Lewis acids was developed. Among them, the iridium catalyst [Ir (cod) Cl] 2 catalyzed the reaction most efficiently.

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