Tetrahedron

An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins

K Nihei, MJ Kato, T Yamane, K Konno

Index: Nihei, Ken-ichi; Kato, Massuo J.; Yamane, Tetsuo; Konno, Katsuhiro Tetrahedron, 2006 , vol. 62, # 35 p. 8335 - 8350

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Citation Number: 2

Abstract

An efficient and versatile synthesis of acylpolyamine spider toxins of all structural types classified by extensive MS analysis has been achieved. By using 2- nitrobenzenesulfonamide as an effective activating and/or protecting group (the Nosyl strategy), the naturally occurring toxins 1–8 corresponding to Types A–F were concisely synthesized in high overall yield.