Synlett

Synthesis of Novel Chiral Thiophene-, Benzothiophene-and Benzofuran-Oxazoline Ligands and their Use in the Enantioselective Pd-CatalyzedAllylation

LF Tietze, JK Lohmann

Index: Tietze, Lutz F.; Lohmann, J. Klaas Synlett, 2002 , # 12 p. 2083 - 2085

Full Text: HTML

Citation Number: 22

Abstract

Abstract Novel thiophene, benzothiophene and benzofuran-oxazoline ligands 6-11 containing a diphenylphosphino group at different positions of the heterocyclic skeleton have been prepared and used in the enantioselective allylation. The advantage of these new ligands is their easy accessibility and their high reactivity. The best results were obtained with ligand 9 to give the product 13 in 97.0% ee with 92% yield in 2 hours at 0 C.