New nitric oxide donating 1, 2, 4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities

M Abdel-Aziz, GEDAA Abuo-Rahma, EAM Beshr…

Index: Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.A.; Beshr, Eman A.M.; Ali, Taha F.S. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3839 - 3849

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Citation Number: 18

Abstract

A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ...