Chemoenzymatic Asymmetric Synthesis of Serotonin Receptor Agonist (R)??Frovatriptan

…, V Gotor, V Gotor??Fernández

Index: Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4842 - 4848

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Citation Number: 4

Abstract

Abstract A simple chemoenzymatic asymmetric route has been developed for the production of antimigraine agent (R)-Frovatriptan. Lipases and oxidoreductases have been identified as ideal biocatalysts for the production of enantiopure adequate synthetic intermediates under safe and environmentally friendly conditions.(S)-3-Hydroxy-2, 3, 4, 9-tetrahydro-1H- carbazole-6-carbonitrile, an optimal building block for the synthesis of the drug, has been ...