Nitrogen bridgehead compounds. Part 50. Vilsmeier??haack acylation of 6, 7, 8, 9??tetrahydro??4H??pyrido [1, 2??a] pyrimidin??4??ones, Part 5

…, I Hermecz, B Podányi, Z Mészáros

Index: Horvath; Hermecz; Podanyi; Meszaros Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 593 - 599

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Citation Number: 12

Abstract

Abstract 6-Methyl-6, 7, 8, 9-tetrahydro-4H-pyrido [1, 2-a] pyrimidin-4-ones 1-5 were subjected to Vilsmeier-Haack acylation with complexes of phosphoryl chloride and different amides. Acylation at position 9 of the pyridopyrim-idines was successful with the iminium salt formed in situ from N-formylpiperidine, N-methylformanilide or N, N-diethylbenzamide, but unsuccessful with the iminium salt formed from N, N-diethylacetamide or N, N-di- ...