Synthesis and NMD A Antagonistic Properties of the Enantiomers of 4??(3??phosphonopropyl) piperazine??2??carboxylic acid (CPP) and of the unsaturated analogue (E) …

…, PL Herrling, W Mueller, HJ Olverman…

Index: Aebischer; Frey; Haerter; Herrling; Mueller; Olverman; Watkins Helvetica Chimica Acta, 1989 , vol. 72, # 5 p. 1043 - 1051

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Citation Number: 106

Abstract

Abstract The (R)-and (s)-enantiomers of 4-(3-phosphonopropyl) piperazine-2-carboxylic acid (D-and L-CPP, resp.; 15 and 16, resp.), and of its unsaturated analogue (E)-4-(3- phosphonoprop-2-enyl) piperazine-2-carboxylic acid (D-and L-CPP-ene, resp.; 13 and 14, resp.) were prepared. The absolute configuration of the enantiomers was determined by a chemical correlation of the menthyl ester 7 with D-asparagine. The affinity of these ...