Binding interactions between 3-aryl-1, 2, 4-oxadiazol-5-ones and a trisimidazoline base

A Reichert, R Fröhlich, R Ferguson…

Index: Reichert, Anja; Froehlich, Roland; Ferguson, Roderick; Kraft, Arno Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 11 p. 1321 - 1328

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Citation Number: 12

Abstract

The use of 1, 2, 4-oxadiazol-5-ones, a recently developed class of bioisosteric replacements for carboxylic acids in medicinal chemistry, as binding ligands in supramolecular complexes is reported and has been exemplified by the formation of non-covalent complexes between acidic 3-aryl-1, 2, 4-oxadiazol-5-ones and an imidazoline base, 1, 3, 5-tris (4, 5- dihydroimidazol-2-yl) benzene 1. The X-ray crystal structure of complex 6d illustrates how ...