Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions

…, P Krogsgaard-Larsen, K Schaumburg…

Index: Brehm, Lotte; Krogsgaard-Larsen, Povl; Schaumburg, Kjeld; Johansen, Joergen S.; Falch, Erik; Curtis, David R. Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 224 - 229

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Citation Number: 20

Abstract

3 12 9 and varying, but small amounts of the P-oxo hydroxamic acid 10. During the column chromatographic (CC) separation procedures using silica gel a new compound was formed in varying quantities depending on the duration of the CC procedures. This latter compound, which could also be made by treatment of 8 with silica gel and the particular CC eluent, was shown to be the 2-isoxazolin-5-one tautomer (11) of 8. This structure assignment is in ...