Synthesis and positive inotropic evaluation of [1, 2, 4] triazolo [3, 4-a] phthalazine and tetrazolo [5, 1-a] phthalazine derivatives bearing substituted piperazine moieties

…, BR Cui, Y Wu, JC Liu, X Cui, LP Liu, HR Piao

Index: Ma, Long-Xu; Cui, Bai-Ri; Wu, Yan; Liu, Jia-Chun; Cui, Xun; Liu, Li-Ping; Piao, Hu-Ri Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1737 - 1741

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Citation Number: 3

Abstract

Abstract Four series of [1, 2, 4] triazolo [3, 4-a] phthalazine and tetrazolo [5, 1-a] phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several compounds were developed and showed favorable activities compared to the standard drug milrinone, with (4-([1, 2, 4] triazolo [3, 4-a] phthalazin-6-yl) ...