Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogs

…, TA Crowell, JA Clemens, BD Sawyer

Index: Flaugh; Crowell; Clemens; Sawyer Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69

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Citation Number: 81

Abstract

A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the. V-acyl group nor was it significantly altered by methylation of position 2 or the 0-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.