Highly Enantioselective Pictet–Spengler Reaction Catalyzed by SPINOL??Phosphoric Acids

D Huang, F Xu, X Lin, Y Wang

Index: Huang, Dan; Xu, Fangxi; Lin, Xufeng; Wang, Yanguang Chemistry - A European Journal, 2012 , vol. 18, # 11 p. 3148 - 3152

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Citation Number: 51

Abstract

Chiral tetrahydro-β-carbolines represent an important class of heterocycles in organic chemistry. They are structural units in a variety of natural products and important pharmaceuticals (Figure 1)[1] and useful intermediates for constructing several drugs, such as tadalafil.[2] Consequently, efficient methods for the preparation of optically pure tetrahydro-β-carbolines are in great demand. Whereas diastereospecific Pictet–Spengler ...