An Efficient Protocol for the Amidation of Carboxylic Acids Promoted by Trimethyl Phosphite and Iodine

QL Luo, L Lv, Y Li, JP Tan, W Nan…

Index: Luo, Qun-Li; Lv, Lina; Li, Yu; Tan, Jian-Ping; Nan, Wenhui; Hui, Qun European Journal of Organic Chemistry, 2011 , # 34 p. 6916 - 6922

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Citation Number: 13

Abstract

Abstract A practical, one-pot protocol is described for the conversion of carboxylic acids into amides through carboxyl activation by the reagent combination of trimethyl phosphite and iodine. This method integrates several advantages:(1) it allows amines to be chemoselectively acylated with excellent results in the presence of sulfur and oxygen nucleophiles;(2) the method shows wide generality in respect of solvent, base, and ...

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