Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists

L Kiefer, T Gorojankina, P Dauban, H Faure…

Index: Kiefer, Lionel; Gorojankina, Tatiana; Dauban, Philippe; Faure, Helene; Ruat, Martial; Dodd, Robert H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7483 - 7487

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Citation Number: 20

Abstract

The design, synthesis and calcimimetic properties of various cyclic sulfonamides and sulfamates are described. The latter were prepared from the corresponding o- alkenylarenesulfonamides via copper-or rhodium-catalyzed intramolecular aziridination. The size of the cyclic sulfonamide rings as well as the position of the crucial (R)- naphthylethylamine substituent significantly affected calcimimetic activity. The most active ...