Fenbufen based 3-[5-(substituted aryl)-1, 3, 4-oxadiazol-2-yl]-1-(biphenyl-4-yl) propan-1-ones as safer antiinflammatory and analgesic agents

…, A Ahmad, MM Alam, M Ajmal, P Ahuja

Index: Husain, Asif; Ahmad, Ausaf; Alam; Ajmal; Ahuja, Priyanka European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3798 - 3804

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Citation Number: 55

Abstract

The synthesis of a series of 3-[5-(substituted aryl)-1, 3, 4-oxadiazol-2-yl]-1-(biphenyl-4-yl) propan-1-ones derived from 4-oxo-4-(biphenyl-4-yl) butanoic acid (fenbufen) is described. The structures of these compounds were supported by IR, 1H NMR, mass spectrometric data and elemental analysis. These compounds were tested for their antiinflammatory, analgesic, ulcerogenic and lipid peroxidation actions. A few compounds were found to have very ...