Simple microwave-assisted method for the synthesis of primary thioamides from nitriles

MC Bagley, K Chapaneri, C Glover, EA Merritt

Index: Bagley, Mark C.; Chapaneri, Krishna; Glover, Christian; Merritt, Eleanor A. Synlett, 2004 , # 14 p. 2615 - 2617

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Citation Number: 20

Abstract

Abstract Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 C or 130 C in 15-30 minutes for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H 2 S under high pressure, proceeds in the absence of base and provides thioamides usually without the ...