Synthesis of a potential M1 muscarinic agent [76Br] bromocaramiphen

…, F Dolle, C Coulon, C Loc'h, B Mazière

Index: Strijckmans; Hunter; Dolle; Coulon; Loc'h; Maziere Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 5 p. 471 - 481

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Citation Number: 12

Abstract

Abstract [76 Br] bromocaramiphen was prepared from the iodo-analogue by a Cu+ nucleophilic bromodeiodination exchange. The radiolabelling yield was 40–45%. The radiochemical and chemical purities assessed by radio-TLC and HPLC were 98%. The precursor, iodocaramiphen, was synthesized from commercially available 1- phenylcyclopentanecarboxylic acid with a 10% overall yield in a 5 step procedure. This ...