A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling

T Fukuyama, M Shinmen, S Nishitani, M Sato…

Index: Fukuyama, Takahide; Shinmen, Masutaka; Nishitani, Satoshi; Sato, Masaaki; Ryu, Ilhyong Organic Letters, 2002 , vol. 4, # 10 p. 1691 - 1694

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Citation Number: 383

Abstract

The PdCl2 (PPh3) 2-catalyzed Sonogashira coupling reaction, in good to high yields, was performed in an ionic liquid ([BMIm][PF6]) in the absence of a copper salt. The use of an ionic liquid allows for the facile separation and recycling of the catalyst. The application of the above reaction in a microflow system in conjunction with an IMM micromixer was also successful.