Dialkyl bicyclic heterocycles with a bridgehead nitrogen as purine analogs possessing significant cardiac inotropic activity

T Okabe, B Bhooshan, T Novinson…

Index: Okabe; Bhooshan; Novinson; et al. Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 735 - 751

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Citation Number: 34

Abstract

Abstract A number of 5, 7-dialkyl-s-triazolo [1, 5-a] pyrimidines and 5, 7-dialkylpyrazolo [1, 5- a] pyrimidines and related heterocycles containing a bridgehead nitrogen have been prepared and studied as cardiovascular agents in the anesthetized dog. A number of these compounds have exhibited significant inotropic activity with little effect on heart rate. Especially active were 5, 7-dialkyl-2-amino or 2-alkylthio-s-triazolo [1, 5-a] pyrimidines. In ...