Synthesis of novel pyrrolyl-indomethacin derivatives
…, D Agas, MG Sabbieti, M Di Magno, A Migliorini…
Index: Serra Moreno, Judith; Agas, Dimitrios; Sabbieti, Maria Giovanna; Di Magno, Matteo; Migliorini, Antonella; Loreto, M. Antonietta European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 391 - 397
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Citation Number: 4
Abstract
In the present work, we report the synthesis of the novel esters of indomethacin (IDMC) and an ester of reduced IDMC. For this purpose, IDMC is covalently bound by using a spacer chain to the pyrrole (Py) in the 3-position. The innovative pyrrole-indomethacin (3-Py-IDMC) derivates show no cytotoxic effects in primary calvarial osteoblasts. The designed IDMC derivates have been studied because they could be injected locally as a component of ...
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