Dicarboxylic acid esters as transdermal permeation enhancers: Effects of chain number and geometric isomers

M Novotný, A Hrabálek, B Janůšová, J Novotný…

Index: Novotny, Michal; Hrabalek, Alexandr; Janusova, Barbora; Novotny, Jakub; Vavrova, Katerina Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 344 - 347

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Citation Number: 15

Abstract

A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was ...