Syntheses of 5-fluoro-d/l-dopa and [18F] 5-fluoro-l-dopa

M Argentini, C Wiese, R Weinreicht

Index: Argentini, Mario; Wiese, Claudia; Weinreich, Regin Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144

Full Text: HTML

Citation Number: 25

Abstract

Abstract This paper describes the synthesis of 5-fluoro-d/l-dopa and the corresponding [18 F] 5-fluoro-l-dopa starting from 5-nitrovanillin via malonic ester synthesis, the Balz- Schiemann reaction and the separation of the racemic mixture [18 F] 5-fluoro-d/l-dopa with a chiral HPLC system. The inactive 5-fluoro-d/l-dopa was obtained in an eight-step synthesis with an overall yield of 10%. For a reliable synthesis, the nitro group was reduced with ...