Substituted 2-(3′, 4′, 5′-trimethoxybenzoyl)-benzo [b] thiophene derivatives as potent tubulin polymerization inhibitors
…, O Cruz-Lopez, M Tolomeo, S Grimaudo…
Index: Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cruz-Lopez, Olga; Tolomeo, Manlio; Grimaudo, Stefania; Cristina, Antonietta Di; Pipitone, Maria Rosaria; Balzarini, Jan; Brancale, Andrea; Hamel, Ernest Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5114 - 5122
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Citation Number: 27
Abstract
The central role of microtubules in cell division and mitosis makes them a particularly important target for anticancer agents. On our early publication, we found that a series of 2- (3′, 4′, 5′-trimethoxybenzoyl)-3-aminobenzo [b] thiophenes exhibited strong antiproliferative activity in the submicromolar range and significantly arrested cells in the G2– M phase of the cell cycle and induced apoptosis. In order to investigate the importance of ...
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