Liquid chromatography/electrospray ionisation mass spectrometric tracking of 4??hydroxy??2 (E)??nonenal biotransformations by mouse colon epithelial cells using [1, 2?? …

…, FHF Pierre, F Guéraud, L Debrauwer

Index: Jouanin; Baradat; Gieules; Tache; Pierre; Gueraud; Debrauwer Rapid Communications in Mass Spectrometry, 2011 , vol. 25, # 19 p. 2675 - 2681

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Abstract

Abstract 4-Hydroxy-2 (E)-nonenal (HNE), a product of lipid peroxidation, has been extensively studied in several areas, including metabolism with radio-isotopes and quantification in various matrices with deuterium-labelled HNE as standard. The aim of this work was to evaluate the relevance of 13 C-labelled HNE in biotransformation studies to discriminate metabolites from endogens by liquid chromatography/electrospray ionisation ...

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