Activation and coupling of pyrrole-1-carboxylic acid in the formation of pyrrole N-carbonyl compounds: pyrrole-1-carboxylic acid anhydride
DL Boger, M Patel
Index: Boger, Dale L; Patel, Mona Journal of Organic Chemistry, 1987 , vol. 52, # 11 p. 2319 - 2323
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Citation Number: 21
Abstract
The preparation [1, 0.5 equiv of EDCI-HC1, methylene chloride, 25" C, 15 min, 87%], isolation-purification, and characterization of pyrrole-1-carboxylic acid anhydride (2) followed by its stoichiometric use in coupling reactions proved to be the most effective and dependable procedure for formation of the pyrrole N-carbonyl compounds derived from unreactive or nonnucleophilic coupling substrates (cf. Table I). In the instances of the use ...
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