Topical nonsteroidal antipsoriatic agents. 1. 1, 2, 3, 4-Tetraoxygenated naphthalene derivatives

…, MC Venuti, JM Young, DVK Murthy…

Index: Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511

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Citation Number: 34

Abstract

On the basis of previous observations that both 2, 3-dihydro-2, 2, 3, 3-tetrahydroxy-l, 4- naphthoquinone (oxoline, 1) and 6-chloroisonaphthazarin (2) had demonstrated antipsoriatic activity in vivo, a series of structural derivatives of 2 were prepared and examined in the Scholtz-Dumas topical psoriasis bioassay. Of these six (5, 6, 9a, 10, lla, 1 lb), the most effective compound was found to be 6-chloro-l, 4-diacetoxy-2, 3- ...