Tricyclic pyridine derivatives with high affinity to the central benzodiazepine receptor

…, H Möhler, F Schneider, U Widmer

Index: Fischer; Mohler; Schneider; Widmer Helvetica Chimica Acta, 1990 , vol. 73, # 4 p. 763 - 781

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Citation Number: 34

Abstract

Abstract Novel tricyclic heterocycles were prepared and evaluated for their affinity to the central benzodiazepine receptor. The most potent compounds with IC 50's in the nanomolar range were; found among thienoquinolizines and benzo [a] quinolizines (cf. Tables 2–5). The central ring of the tricyclic ring system may be partially unsaturated (cf. Tables 2 and 4) or fully unsaturated (cf. Tables 3 and 5) without loss of the high affinity to the receptor. The ...