Analogs of. alpha.-methylphenethylamine (amphetamine). I. Synthesis and pharmacological activity of some methoxy and/or methyl analogs

BT Ho, WM McIsaac, R An, LW Tansey…

Index: Ho,B.T. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 26 - 30

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Citation Number: 27

Abstract

Chemistry.-The amines n ere prepared by the condensation of nitroethane n ith the corresponding aldehyde folloned by LiAlH, reduction of the resulting phenylnitropropene. S o attempt was made to purify the intermediate phenylnitropropenes. The aldehyde required for the preparation of 4 was obtained from 3-methoxy-p-toluic acid. Treatment of the acid with SOClz afforded the acid chloride, nhich nas then reduced to 3-methoxy-p- ...