Di-oxanipecotic acids as more stable turn motifs than di-nipecotic acids
B Baek, M Lee, KY Kim, UI Cho, DW Boo, I Shin
Index: Baek, Bong-Hyeon; Lee, Myung-Ryul; Kim, Kwang-Yon; Cho, Ung-In; Boo, Doo Wan; Shin, Injae Tetrahedron Letters, 2003 , vol. 44, # 17 p. 3447 - 3450
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Citation Number: 3
Abstract
The folded structures of peptidomimetics containing dimers of oxanipecotic acid (Oxa) in loop segments were characterized and compared with those of the corresponding nipecotic acid (Nip)-based ones. According to structural studies using FT-IR and NMR spectroscopies, di-oxanipecotic acid adopted more stable turn conformations than di-nipecotic acid, and for tetramers, L,(S)-Oxa,(S)-Oxa, L and L,(S)-Oxa,(R)-Oxa, L formed hairpin-like structures but ...
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