Analogs and derivatives of tenoxicam. 1. Synthesis and antiinflammatory activities of analogs with different residues on the ring nitrogen and the amide nitrogen

…, O Hromatka, F Geissler, K Schmied…

Index: Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682

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Citation Number: 31

Abstract

The synthesis of tenoxicam, 4-hydroxy-2-methyl-N2-pyridyl-W-thieno [2, 3-e]-1, 2-thiazine-3- carboxamide 1, l-dioxide (le), and of the analogues with various residues on the, ring nitrogen and the amide nitrogen is described. This new class of" oxicams" has pronounced antiinflammatory and analgesic properties. The very specific structureactivity relationship of isomeric and isosteric groups at the amide nitrogen has been evaluated. The substituent ...