NH2 As a Directing Group: From the Cyclopalladation of Amino Esters to the Preparation of Benzolactams by Palladium (II)-Catalyzed Carbonylation of N-Unprotected …

…, M Font-Bardia, J Garcia, J Granell, A Lamela…

Index: Albert, Joan; Ariza, Xavier; Calvet, Teresa; Font-Bardia, Merce; Garcia, Jordi; Granell, Jaume; Lamela, Andrea; Lopez, Blanca; Martinez, Manuel; Ortega, Laura; Rodriguez, Aleix; Santos, David Organometallics, 2013 , vol. 32, # 2 p. 649 - 659

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Citation Number: 23

Abstract

An unusual NH2-directed Pd (II)-catalyzed carbonylation of quaternary aromatic α-amino esters to yield benzolactams has been developed. The steric hindrance around the amino group is pivotal for the success of the process. The stoichiometric cyclometalation of a variety amino esters has been studied in order to evaluate the influence of the different variables (size of the metallacycle, aromatic ring substituents, and steric bulk) in the ...