Enantioselective annulation reactions of bisenolates prepared through dearomatization reactions of aromatic and heteroaromatic diesters

J Pérez??Vázquez, AX Veiga, G Prado…

Index: Perez-Vazquez, Jaime; Veiga, Alberte X.; Prado, Gustavo; Sardina, F. Javier; Paleo, M. Rita European Journal of Organic Chemistry, 2012 , # 5 p. 975 - 987

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Citation Number: 2

Abstract

Abstract A one-pot, enantioselective strategy for the dearomatization–annulation of aromatic diesters to give a range of highly functionalized polycyclic molecules with excellent enantioselectivity is presented. This methodology is based on the reaction of bisenolates, prepared by treating aromatic diesters with trialkyltin lithium reagents, which involves a stanna-Brook rearrangement, with 1, ω-dihaloalkanes and other biselectrophiles. We ...