Archiv der Pharmazie

Synthesis and Histamine H3 and H4 Receptor Activity of Conformationally Restricted Cyanoguanidines Related to UR??PI376

R Geyer, A Buschauer

Index: Geyer, Roland; Buschauer, Armin Archiv der Pharmazie, 2011 , vol. 344, # 12 p. 775 - 785

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Citation Number: 17

Abstract

Abstract Recently, we identified highly potent agonists of the human histamine H 4 receptor (hH 4 R) among a series of imidazolylbutylcyanoguanidines. Aiming at improved selectivity for the hH 4 R relative to the H 3 receptor (hH 3 R), the flexible tetramethylene linker connecting imidazole ring and cyanoguanidine group was replaced by conformationally restricted carbocycles. Introduction of a para-or a meta-phenylene spacer yielded only ...