Pd (II)-Catalyzed Carbonylation of C (sp3)− H Bonds: A New Entry to 1, 4-Dicarbonyl Compounds

EJ Yoo, M Wasa, JQ Yu

Index: Yoo, Eun Jeong; Wasa, Masayuki; Yu, Jin-Quan Journal of the American Chemical Society, 2010 , vol. 132, # 49 p. 17378 - 17380

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Citation Number: 162

Abstract

Pd (II)-catalyzed β-C (sp3)− H carbonylation of N-arylamides under CO (1 atm) has been achieved. Following amide-directed C (sp3)− H cleavage and insertion of CO into the resulting [Pd (II)− C (sp3)] bond, intramolecular C− N reductive elimination gave the corresponding succinimides, which could be readily converted to 1, 4-dicarbonyl compounds. This method was found to be effective with substrates containing α-hydrogen ...