Synthetic electroorganic chemistry. 14. Synthesis of 5-fluorouracil derivatives having N-acylazacycloalkanes and lactams

T Nishitani, H Horikawa, T Iwasaki…

Index: Nishitani; Horikawa; Iwasaki; et al. Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1706 - 1712

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Citation Number: 35

Abstract

5-Fluorouracil derivatives have been synthesized, in 41-84% yield, by the Lewis acid catalyzed condensation of 2, 4-bis (trimethylsilyl)-5-fluorouracil with N-acyl-2- methoxyazacycloalkanes; the latter have been prepared by anodic oxidation of either N- acylprolines and N-acylpipecolic acids in methanolic sodium methoxide or N- acylperhydroazepines and N-acylmorpholines in methanolic tetraethylammonium ...