Hydantoins and thiohydantoins derived from 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid
P Jansa, V Wsol, V Bertolasi, V Machacek
Index: Jansa, Petr; Wsol, Vladimir; Bertolasi, Valerio; Machacek, Vladimir Heterocycles, 2006 , vol. 68, # 12 p. 2527 - 2547
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Abstract
Résumé/Abstract The reaction of methyl (5)-l, 2, 3, 4-tetrahydroisoquinoline-3-carboxylate with isocyanates (phenyl, naphthalen-1-yl, cyclohexyl,(S)-1-methylbenzyl) in ether has been used to prepare N-substituted methyl (3S)-2-aminocarbonyl-1, 2, 3, 4-tetrahydroisoquinoline- 3-carboxylates. These compounds were cyclised by action of CF 3 COOH to give the corresponding 2-substituted (1 0aS)-10, 1Oa-dihydroimidazo [1, 5-b] isoquinoline-1, 3 (2H ...
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