Addition of glycinate enolate equivalents to 1, 4-benzodiazepine imino phosphates. Preparation of synthetically useful 2-(ethyl glycinat-. alpha.-ylidene)-1, 4- …

RI Fryer, LV Kudzma, ZQ Gu, KY Lin…

Index: Fryer, R. Ian; Kudzma, Linas V.; Gu, Zi-Qiang; Lin, Kuei-Ying Journal of Organic Chemistry, 1991 , vol. 56, # 11 p. 3715 - 3719

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Citation Number: 10

Abstract

19 (37) aReactions were performed under an atmosphere of dry argon under the following conditions:(a)-78 OC to rt (18 h);(b) 0 OC to rt (18 h);(c)-78" C to rt, followed by reflux for 18 h.* Isolated yield after crystallization or flash chromatography. 12 in good yield (Table I). Deprotonation of 6 is rather slow at-78 OC due to the bulky disilazane. If insufficient time is allowed for deprotonation of 6 (< 40 min) prior to addition of the imino phosphate, variable ...