Microwave??Assisted Beckmann Rearrangement: Convenient Synthesis of 1, 3??Diaza??bicyclo [3.2. 2] nonane

…, TG Pagano, M Gopalakrishnan, R Faghih

Index: Curtis, Michael P.; Bunnelle, William H.; Pagano, Thomas G.; Gopalakrishnan, Murali; Faghih, Ramin Synthetic Communications, 2006 , vol. 36, # 3 p. 321 - 326

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Citation Number: 4

Abstract

Abstract Small heterocyclic amines such as 1, 3??diaza??bicyclo [3.2. 2] nonane are known to be key components of biologically active molecules. A convenient synthesis of this compound utilizing a key Beckmann rearrangement of (Z)??1??aza??bicyclo [2.2. 2] octan??3?? one oxime (6) with conc. H2SO4 under microwave irradiation was achieved. The desired compound (1) was obtained in 20% yield overall.