Tetrahedron: Asymmetry

An optimised synthetic approach to a chiral derivatising agent and the utilisation of a dimerisation reaction in the synthesis of a novel C2-symmetric diphosphine …

GD Williams, CE Wade, GJ Clarkson, M Wills

Index: Williams, Glynn D.; Wade, Charles E.; Clarkson, Guy J.; Wills, Martin Tetrahedron Asymmetry, 2007 , vol. 18, # 5 p. 664 - 670

Full Text: HTML

Citation Number: 12

Abstract

We report an optimised synthetic approach to the chiral derivatising agent (5R)-methyl-1- (chloromethyl)-2-pyrrolidinone. In addition, the observation of an unwanted dimerisation product is turned to our advantage by providing a method for the synthesis of a new class of C2-symmetric chiral diphosphine.

Related Articles:

Total synthesis of pinnamine and anatoxin-a via a common intermediate. A caveat on the anatoxin-a endgame

[Hjelmgaard, Thomas; Sotofte, Inger; Tanner, David Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5688 - 5697]

Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N??Heterocyclic Carbenes Derived from (S)??Pyroglutamic Acid

[Aupoix, Audrey; Bournaud, Chloee; Vo-Thanh, Giang European Journal of Organic Chemistry, 2011 , # 15 p. 2772 - 2776]

More Articles...