Novel non-benzimidazole chk2 kinase inhibitors

…, A Brunmark, J Blevitt, JG Breitenbucher

Index: McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928

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Citation Number: 20

Abstract

In a recent paper,[Arienti, KL; Brunmark, A.; Axe, FU; McClure, KM; Lee, A.; Blevitt, J.; Neff, DK; Huang, L.; Crawford, S.; Chennagiri, RP; Karlsson, L.; Brietenbucher, JGJ Med. Chem. 2005, 48, 1873], we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound 1, which had radio-protective effects in human T-cells subjected to ionizing radiation. Here, a series of non-benzimidazole analogs intended to ...