In vitro antimycobacterial activity of 5-chloropyrazinamide
MH Cynamon, RJ Speirs, JT Welch
Index: Cynamon, Michael H.; Speirs, Robert J.; Welch, John T. Antimicrobial Agents and Chemotherapy, 1998 , vol. 42, # 2 p. 462 - 463
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Citation Number: 69
Abstract
ABSTRACT 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.
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