N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors

RA Olsson, S Kusachi, RD Thompson…

Index: Olsson; Kusachi; Thompson; Ukena; Padgett; Daly Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689

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Citation Number: 70

Abstract

The coronary vasoactivity of N-ethyl-l'-deoxy-l'-(6-amino-SH-purin-9-yl)-~-~-ribofuran~ on~ ide (NECA, 1) is over 2 orders of magnitude greater than that of adenosine, and the vasoactivity of certain Ns-substituted adenosines is as much as 1 order of magnitude greater. Such results suggest that a combination of appropriate modifications at N6 and C- 5'might additively augment the agonist potency of adenosine. At low temperatures 1- ...