Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA)
J Vergnaud, PA Faugeras, V Chaleix, Y Champavier…
Index: Vergnaud, Julien; Faugeras, Pierre-Antoine; Chaleix, Vincent; Champavier, Yves; Zerrouki, Rachida Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6185 - 6189
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Citation Number: 3
Abstract
We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied
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