Alkyl (E, Z)??2??(2??benzoyl??2??ethoxycarbonyl??1??ethenyl) amino??3??dimethylaminopropenoates in the synthesis of fused pyrimidinones. A facile route to 3??aminoazino?? …

…, A Golobič, L Golič, B Stanovnik

Index: Strah, Sonja; Golobic, Amalija; Golic, Ljubo; Stanovnik, Branko Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1511 - 1517

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Citation Number: 12

Abstract

Abstract Alkyl (E, Z)-2-(2-benzoyl-2-ethoxycarbonyl-1-ethenyl) amino-3- dimethylaminopropenoates 1a, b react with het-eroarylamines 2 to give alkyl 2-(2-benzoyl-2- ethoxycarbonyl-1-ethenyl) amino-3-heteroarylaminopropenoates 3-13. These were cyclized into fused 3-(2-benzoyl-2-ethoxycarbonyl-1-ethenyl) amino-4H-azolo-(or azino)-pyrim-idin-4- ones 14-18. 2-Benzoyl-2-ethoxycarbonyl-1-ethenyl group can be easily removed from 3-( ...