Synthesis of some new 5-(2-substituted-1, 3-thiazol-5-yl)-2-hydroxy benzamides and their 2-alkoxy derivatives as possible antifungal agents

B Narayana, KKV Raj, BV Ashalatha, NS Kumari…

Index: Narayana; Vijaya Raj; Ashalatha; Kumari, N. Suchetha; Sarojini European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 867 - 872

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Citation Number: 76

Abstract

The 2-hydroxy-5-(1, 3-thiazol-5-yl) benzamide (4a), 5-(2-amino-1, 3-thiazol-5-yl)-2-hydroxy benzamide (4b), 2-hydroxy-5-(2-alkyl-1, 3-Thiazol-5-yl) benzamide (4c and 4d), 5-{2-[(N- substituted aryl) amino]-1, 3-thiazol-5-yl} 2-hydroxy benzamides (6a–j) were prepared by reacting 5-(bromoacetyl) salicylamide (2) with thiourea, thioformamide, thioalkylamide (3c– d) and substituted thioureas (5a–j) in absolute ethanol. These compounds were converted ...