3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency
IM Bell, SN Gallicchio, M Abrams…
Index: Journal of Medicinal Chemistry, , vol. 45, # 12 p. 2388 - 2409
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Citation Number: 86
Abstract
... Journal of Medicinal Chemistry. ... Chemical Methods. Scheme 1 describes the synthetic steps that were generally used for the construction of these macrocyclic FTIs, with compound 11 as an example. Commercially ...
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[Journal of Medicinal Chemistry, , vol. 46, # 14 p. 2973 - 2984]
[Journal of Medicinal Chemistry, , vol. 46, # 14 p. 2973 - 2984]