Letters in Organic Chemistry

A Novel Synthesis of 1, 4, 7, 10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt

R Huang, C Xie, L Huang, J Liu

Index: Huang, Rui; Xie, Chunsong; Huang, Lin; Liu, Jinhua Letters in Organic Chemistry, 2013 , vol. 10, # 3 p. 195 - 198

Full Text: HTML

Citation Number: 4

Abstract

1, 4, 7, 10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1, 4, 7, 10- Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.